CIRCULATING ANGIOGENIC FACTOR LEVELS IN HYPERTENSIVE DISORDERS OF PREGNANCY
Keywords:
Material and Methods. In 18 U.S. centers scientists prospectively measured the ratio of serum soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) in pregnant women hospitalized between 23 and 35 weeks of gestation. The primary outcome was predicting sPE, and secondary outcomes included predicting adverse outcomes within 2 weeks. The prognostic performance of the sFlt-1:PlGF ratio was assessed by using a derivation/validation design.Abstract
Hypertensive disorders in pregnancy (HDPs), defined as prepregnancy (chronic) or pregnancy-associated hypertension, are common pregnancy complications. HDPs are strongly associated with severe maternal complications, such as heart attack and stroke, and are a leading cause of pregnancy-related death. Among women with hypertensive disorders of pregnancy, biomarkers may stratify risk for developing preeclampsia with severe features (sPE).
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