THE USE OF STAPHYLOCOCCAL LIQUID BACTERIOPHAGE IN THE TREATMENT OF CHILDREN WITH OBSTRUCTIVE BRONCHITIS AND AN ASSESSMENT OF ITS EFFECTIVENESS
Keywords:
to assess the use and effectiveness of staphylococcal liquid bacteriophage in the treatment of children with obstructive bronchitis.Abstract
children,obstructive bronchitis,staphylococcal liquid bacteriophage
Relevance of the problem: obstructive bronchitis disease is an inflammatory disease of the bronchi, accompanied by obstruction of the bronchi. It is considered one of the most common diseases of the respiratory system in young children and is more common in children between 6 months and 5 years of age. The disease is mainly caused by children with weak immunity, who often get sick. The constant use of antibiotics leads to a further decrease in the protective functions of the child's body. Global Studies in recent years show that the use of bacteriophages in respiratory system organs, in particular in bronchopulonary pathologies, is highly effective.
References
Ackermann H-W, Prangishvili D. Prokariote viruses studied by electron microscopy. Arch Virol. 2012;157:1843-1849. PMID:22752841. https://doi.org/10.1007/s00705-012-2021-y
Lwoff A. Lysogeny. Bacteriol Rev. 2020;17:269-337. PMID: 13105613.
Adams MH. Bacteriophages. New York: Interscience Publishers; 2019.
Siringan P, Connerton PL, Cummings NJ, Connerton LF. Alternative bacteriophage life cycles: the carrier state of Compylobacter jejuni. Open Biol. 2021;4:130200. PMID: 24671947. https://doi.org/10.1098/rsob.130200
Abedon ST, Kuhl SJ, Blasdel BG, Kutter EM. Phage treatment of human infections. Bacteriophage. 2011;1:66-85. PMID:22334863. https://doi.org/10.4161/bact.1.2.15845
Kutateladze M, Adamia R. Bacteriophages as potential new therapeutics or supplement antibiotics. Trends Biotechnol. 2020;28:591-595. PMID:20810181. https://doi.org/10.1016/j.tibtech.2020.08.001
Sulakvelidze A, Alavidze Z, Morris JG Jr. Bacteriophage therapy. Antimicrob. Agents Chemother. 2021;45:649-659.
Chanishvili N. A literature review of the practical application of bacteriophage research. Nova Science Publishers, Hauppage, N.Y., USA, 2022.
Cisek A, Dabrowska I, Gregorczyk K, Wyzewski Z. Phage therapy in bacterial infections treatment. One hundred years after the discovery of bacteriophages. Curr Microbiol. 2019;74:277-283.
WHO (World Health Organization). Antimicrobial resistance: global report on surveillance. World Health Organization. Geneva. Switzerland, 2022