DYNAMICS OF THE LEVEL OF PRO-INFLAMMATORY CYTOKINES IN VARIOUS VARIANTS OF ACUTE MYOCARDIAL INFARCTION
Keywords:
As shown by numerous recent studies, the severity of immunoinflammatory reactions in patients with unstable forms of coronary heart disease is higher than in patients with a stable course of the diseaseAbstract
At present, it is inflammation that is considered as one of the leading links in the pathogenesis, course, and prognosis of coronary heart disease (CHD) [1, 2]. It also plays a significant role in the development of acute myocardial infarction (MI) and the outcome of the disease, namely, in the formation of atherothrombosis, alteration, necrosis, and repair, followed by myocardial remodeling [3–5].
References
Turdiev U. M. GENETIC FACTORS OF ATHEROSCLEROTIC LESION OF THE CORONARY ARTERIES IN PATIENTS WITH EARLY DEVELOPMENT OF ACUTE CORONARY SYNDROME //European journal of molecular medicine. – 2022. – Т. 2. – №. 5.
Litvin E.I. Rol mediatorov vospaleniya v patogenese ostrogo coronarnogo syndroma [The role of inflammatory mediators in pathogenesis of acute coronary syndrome] // Vrachebnaya practika – Doctor’s practice. 2005; 4: 31–34. (in Russian).
Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease // N. Engl. J. Med. 2005; 352: 1685–1695.
Bodi V., Sanchis J., Nunez J.. Uncontrolled immune response in acute myocardial infarction: unraveling the thread // Am. Heart. J. 2008; 156(6): 1065–1073.
Chukaeva I.I., Bogova O.T., Korochkin I.M. et al. Infarct myocarda I vospalenie [Myocardial infarction and inflammation] // Medicina neotlojnih sostoyaniy – Medical Emergency Conditions. 2007; 4 (11): 19–23 (in Russian).
Thygesen K., Alpert J.S., White H.D. Universal definition of myocardial infarction // J. Am. Coll. Cardiol. 2007; 50: 2173–2195.
Aymong E.D. et al. Pathophysiology of cardiogenic shock complicating acute myocardial infarction // Med. Clin. North. Am. 2007; 91(4): 701–12; XII.
Talaeva TV, Bratus VV. Rol systemnogo vospaleniya v razvitii ostrogo coronarnogo syndrome [Role of systemic inflammation in the development of acute coronary syndrome] // Ukrainskiy kardiologicheskiy jurnal – Ukrainian Journal of Cardiology. 2009; Dodatok 1: 218– 240 (in Russian).
Chereshnev V.A., Gusev E.Yu. Immunologicheskie i patofisiologicheskie mehanizmi sistemnogo vospaleniya [Immunological and pathophisiological mechanisms of systemic inflammation] // Medicinskaya immunologiya – Medical Immunology. 2012; 14 (1–2): 9–20.
Mezhirova NM, Danilova VV, Ovcharenko SS. Patofisiologicheskie I diagnosticheskie aspect syndrome systemnogo dospalitelnogo onveta [Pathophysiological and diagnostic aspects of systemic inflammatory response syndrome] // Medicina neotlojnih sostoyaniy – Medical Emergency Conditions. 2011; 1 (2): 32–33 (in Russian).
Passoni F., Morelli В., Seveso G. et al. Comparative short-term prognostic value of hemostatic and inflammatory markers in patients with non-ST elevation acute coronary syndromes // Ital. Heart J. 2002; 3: 28–35.
Chukaeva I.I., Orlova N.V., Spiryakina Ya.G. et al. Izuchenie cytokinovoi aktivnosti u bolnyh ostrym infarctom myokarda [Study of cytokine activity in patients with acute myocardial infarction] // Rossiyskiy kardiologicheskiy jurnal – Russian Journal of Cardiology. 2010; 4: 5–10. ( in Russian).
Liaudet L., Rosenblatt-Velin N. Role of innate immunity in cardiac inflammation after myocardial infarction // Front. Biosci (Schol. Ed.) 2013; 5: 86–104.
Kachkovskii M.A., Rogozina E.J., Chekuldaeva L.E., Suvorov A.E. Ocenka vlijanija intensivnosti sistemnoy vospalitelnoy reakcii na razmer nekroza miokarda po dannym morfometricheskogo issledovanija [Assessing the impact intensity of systemic inflammatory response to the size of myocardial necrosis according to morphometric study] // Morfologicheskie vedomosti – Morphological Gazette. 2013; (3): 53–6 (in Russian).
Teplyakov A.T., Grakova E.V., Berezikova E.N., Shilov S.N., Kopieva K.V., Kalyuzhin V.V. Rannie marker progressirovanija serdechnoi nedostatochnosti I apoptoza [Early markers of progression of heart failure and apoptosis: their role in predicting the risk of adverse cardiovascular events in patients with prior myocardial infarction] // Bulleten sibirskoy mediciny – Bulletin of Siberian Medicine. 2016; 15 (1): 37–46 (in Russian).
Seropian I.M., Toldo S., Van Tassell B.W., Abbate A. (2014) AntiInflammatory Strategies for Ventricular Remodeling Following ST Segment Elevation Acute Myocardial Infarction // J. Am. Coll. Cardiol. 63: 1593–1603.
Van de Werf F., Bax J., Betriu A. et al. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: The Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology // Eur. Heart J. 2008; 29: 2909–2945.
Antman E.M., Hand M., Armstrong P.W. et al. 2007 Focused Update of the ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: Developed in Collaboration With the Canadian Cardiovascular Society Endorsed by the American Academy of Family Physicians: 2007 Writing Group to Review New Evidence and Update the ACC/ AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction, Writing the Management of Patients With ST-Elevation Myocardial Infarction, Writing on Behalf of the 2004 Writing Committee // Circulation. 2008; 117: 296–329.
Diagnostika I lechenie bolnyh ostrym infarktom myokarda s podemom segmenta ST [Diagnostic and Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: Russian guidelines report of the Russian scientific cardiologic society] // Kardiovaskuljarnaja terapija I profilaktika – Cardiovascular therapy and prevention. 2007; 6 (8): 1–66 (in Russian).
Neskovic A.N., Otasevic P., Bojic M., Popovic A.D. Association of Killip class on admission and left ventricular dilatation after myocardial infarction: a closer look into an old clinical classification // Am. Heart J. 1999; 137: 361–7.
Khot U.N., Jia G., Moliterno D.J., et al. Prognostic importance of physical examination for heart failure in non-ST-elevation acute coronary syndromes: the enduring value of Killip classification // JAMA. 2003; 290: 2174–81.
Fox K.A., Goodman S.G., Klein W. et al. Management of acute coronary syndromes. Variations in practice and outcome; findings from the Global Registry of Acute Coronary Events (GRACE) // Eur. Heart J. 2002; 23: 1177–1189.
Yakushin S.S., Furmenko G.I., Anikina S.A. Epidimiologicheskie osobennosti ostroy koronarnoy patologii u jenschin [Epidemiological peculiarities of acute coronary pathology in women. Trial RESONANS results] // Problemi jenskogo zdorovija – Problems of women health. 2010: 2 (5): 5–11 (in Russian).
Novikova N.A., Gendlin G.E., Storoghakov G.I. Gendernye razlichija u bolnyh ostrym infarktom miokarda [Gender differences in patients with acute coronary syndrome] // Serdechnaja nedostatochnost – Heart falure. 2008: 3 (47): 137–143 (in Russian).
Lee P.Y., Alexander K.P., Hammill B.G. et al. Representation of elderly persons and women in published randomized trials of acute coronary syndromes // JAMA. 2001; 286: 708–713.
Wenger N. K. Clinical characteristics of coronary heart disease in women, emphasis on gender differences // Cardiovasc. Res. 2002; 53: 558–567.
Rebrova O.Yu. Statisticheskiy analiz medicinskih dannyh [Statistical analysis of medical data. The use of the application package STATISTICA] // M.: MediaSfera Publ., 2002: 312 (in Russian).
Organov R.G., Zakirova N.E., Zakirova A.N. et al. Immunovospalitelnye reakcii pri ostrom koronarnom syndrome [Immuno-inflammatory responses in acute coronary syndrome] // Racionalnaja farmakoteratija v kardiologii- Rational pharmacotherapy in cardiology. 2007; 5: 15–19 (in Russian).
Kinlay S., Ganz P. Role of endothelial dysfunction in coronary artery disease and implications for therapy // Am. J. Cardiol. 1997; 80: 11I–16I.
Muratovich T. U. Importance of cardio markers in the diagnosis of myocardial infarction //Texas Journal of Medical Science. – 2023. – Т. 21. – С. 20-22..
Muratovich T. U. Dynamics of Cardiomarkers in Various Degrees of Severety of Acute Myocardial Infarction in Comorbidity //EUROPEAN JOURNAL OF INNOVATION IN NONFORMAL EDUCATION. – 2023. – Т. 3. – №. 3. – С. 26-29.
Konstantinova E.V., Konstantinova N.A. Kletochnye I molekuljarnye mehanizmy vospalenija v patogeneze infarkta miokarda [Cellular and molecular mechanisms of inflammation in pathogenesis of myocardial infarction] // Bulleten RGMU – Bulletin of RSMU/ 2010; (1): 60–64 (in Russian).
Pavlikova E.P., Merai I.A. klinicheskoe znachenie interleykina-6 I faktora nekroza opuholi pri ishemicheskoi bolezni serdca [Clinical value of interleukin-6 and tumor necrosis factor in ischemic heart disease] // KardiologijaCardiology. 2003; 8: 68–71 (in Russian).
Lindmark E., Diderholm E., Wallentin L., Siegbahn A. Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or noninvasive strategy // JAMA. 2001; 286: 2107–13.
Feldman A.M. The role of tumor necrosis factor in the pathophysiology of heart failure // J. Am. Coll. Cardiol. 2000; 35: 537–544.
