FEATURES OF THE PATHOGENESIS OF PERINATAL CENTRAL NERVOUS SYSTEM LESIONS IN NEWBORNS
Keywords:
newborns, perinatal lesions of the central nervous system, pathogenetic features.Abstract
This study aimed to investigate the impact of intrauterine infection and maternal obstetric and gynecological history on the condition of newborns with perinatal lesions of the central nervous system. The study included 103 newborns with perinatal central nervous system lesions, and the findings indicate that the presence of intrauterine infection significantly affects the condition of the newborn at birth. Additionally, it was found that in newborns with perinatal central nervous system damage and hemostasis disorders, careful attention to the mother's pregnancy and clinical symptoms is crucial. Moreover, the study revealed that the burdened obstetric and gynecological history of mothers, particularly in cases of hypoxic-ischemic encephalopathy, can impact the intrauterine development of the fetus, leading to subsequent neurological changes in newborns. These findings underscore the importance of monitoring and addressing maternal health and obstetric history in the context of perinatal central nervous system lesions, as well as the need for targeted interventions to support the health of both mothers and newborns.
References
Barashnev, Yu.I. Perinatal neurology / Yu.I. Barashnev. M. Triad-X, 2001. – 640 p.
Hasanov A. I., Asadova T. A. A modern view on perinatal damage to the central nervous system in newborn children (literature review) //National Journal of Neurology. – 2017. – №. 1 (12). 17-22
Ivanov D. O. Clinical recommendations (protocols) on neonatology. St. Petersburg: Inform Navigator, 2016; pp. 64-82.
Klitochenko G. V., Malyuzhinskaya N. V. Etiology, pathogenesis and diagnosis of perinatal damage to the nervous system in children //Medicinal Bulletin. – 2019. – Vol. 13. – No. 1. – pp. 38-41.
Kulakov V. I., Antonov A. G., Baibarina E. N. Problems and prospects of nursing children with extremely low body weight at the present stage. Russian Bulletin of Perinatology and Pediatrics 2006; (4): 8-11.
Lim V.I., Muradova D.A., Lim M.V. The state of echocardiographic parameters in newborns with perinatal damage to the central nervous system. Problems of biology and medicine. 2021, No.1.1 (126). pp.166-169.
Nechaev V.N., Chernenkov Yu.V., Averyanov A.P., Utts I.A. Perinatal lesions of the central nervous system in newborns according to the data of the Clinical Perinatal Center of the Saratov region. //Saratov Journal of Medical Science 2018; 14 (4): 639-645.
Shabalov, N.P. Neonatology: studies. manual: in 2 volumes / N.P. Shabalov. – 5th ed., ispr. and add. – M.: MEDpress-inform, 2009. – Vol. 1. – 608 p.
Yatsyk G. V., Bombardirova E. P., Tokovaya E. I. Neuropsychic development of deeply premature infants. Detsky Doktor 2001; (3): 8-12.
Grasselli C. Toll-like receptor 4 modulation influences human neural stem cell proliferation and differentiation / C. Grasselli, D. Ferrari, C. Zalfa, M. Soncini, G. Mazzoccoli, F.A. Facchini, L. Marongiu, F. Granucci, M. Copetti, A.L. Vescovi, F. Peri, L. De Filippis // Cell Death Dis. – 2018. – Vol. 15. – №9 (3).P.280.
Сирожиддинова Х.Н. Ортикбоева Н. Т., Набиева Ш. М., Абдухалик-Заде Г.А. Иммунизация часто болеющих детей при лечении респираторных заболеваний. Uzacademia ilmiy-uslubiy jurnali vol 2, issue 1 (11), march 2021. 9-13 бет.
Sirojiddinova X.N. Abdullayeva M.N. Formation of circulating immune complexes (CIC) and immunoglobulins in intrauterine infection (IUI). European science review, Austria, Vienna, 2016. - № 9-10. - Р. 134-135.
Sirojiddinova X.N., Nabieva Sh.M., Ortikboyeva N.T. Intrauterine infection as a developmental factor perinatal pathology // Central asian journal of medical and natural sciences Volume: 02 Issue: 01 | Jan-Feb 2021 ISSN: 2660-4159. On page 107-111.
Sirojiddinova X.N., Ikromova Z.X., Nabiyeva Sh.M., Ortikbayeva N.T., Abdullayeva G.D. Metabolic Changes Following Post-Hypoxic Complications in Newborns // International Journal of Current Research and Review DOI: http://dx.doi.org/10.31782/IJCRR.2020.122229. Scopus. On page 173-177.
Sirojiddinova X.N., Abduxalik-zade G.A., Nabiyeva Sh. M., Rustamova X.X. Clinical symptoms and features of the course of respiratory infection in frequently sick and episodically sick children. IJIEMR Transactions, online available on 11th April 2021 Vol 10. On page 122-125.
