GLYUKONEOGENEZ JARAYONINING BIOXIMIK BORISH MEXANIZMI
Keywords:
Glikogen, glikogenoliz, tregilitserid, gepatotsit, alanin, mitoxondriyaAbstract
Glyukoneogenez ochlik paytida qonda glyukoza miqdorini normallashtirib turadigan mitoxondriya va sitozoldagi reaksiyalarga aytiladi. Glyukoneogenez jarayoni mahalliy yoki markaziy ( insulin, glyukagon va kortizol) tomonlama boshqarib turiladi. Rag’batlantiruvchi va ingibirlovchi gormonlar o’rtasidagi muvozanat glyukoneogenez tezligini tartibga solib turadi. Jigar va buyraklar turli to’qimalarni aylanma qon glyukoza bilan ta’minlaydigan organlardir. Turli to’qimalarda ochlik vaqtida glyukoza hosil qilish uchun ko’plab mexanizmlar mavjud bo’lib, ularning to’g’ri ishlashi uchun yetarli energiya darajasini saqlab turadi.
References
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SCHEINBERG P. OBSERVATIONS ON CEREBRAL CARBOHYDRATE METABOLISM IN MAN. Ann Intern Med. 1965 Feb;62:367-71.
Chandramouli V, Ekberg K, Schumann WC, Kalhan SC, Wahren J, Landau BR. Quantifying gluconeogenesis during fasting. Am J Physiol. 1997 Dec;273(6):E1209-15.
Gerich JE, Meyer C, Woerle HJ, Stumvoll M. Renal gluconeogenesis: its importance in human glucose homeostasis. Diabetes Care. 2001 Feb;24(2):382-91.
Felig P. The glucose-alanine cycle. Metabolism. 1973 Feb;22(2):179-207.
Draoui N, Feron O. Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments. Dis Model Mech. 2011 Nov;4(6):727-32.
Ferrannini E, Barrett EJ, Bevilacqua S, DeFronzo RA. Effect of fatty acids on glucose production and utilization in man. J Clin Invest. 1983 Nov;72(5):1737-47.
Yip J, Geng X, Shen J, Ding Y. Cerebral Gluconeogenesis and Diseases. Front Pharmacol. 2016;7:521
Jiang G, Zhang BB. Glucagon and regulation of glucose metabolism. Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E671-8.
Adina-Zada A, Zeczycki TN, Attwood PV. Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA. Arch Biochem Biophys. 2012 Mar 15;519(2):118-30.
.Zhang X, Yang S, Chen J, Su Z. Unraveling the Regulation of Hepatic Gluconeogenesis. Front Endocrinol (Lausanne). 2018;9:802. [PMC free article] 2.Lin HV, Accili D. Hormonal regulation of hepatic glucose production in health and disease. Cell Metab. 2011 Jul 06;14(1):9-19.
SCHEINBERG P. OBSERVATIONS ON CEREBRAL CARBOHYDRATE METABOLISM IN MAN. Ann Intern Med. 1965 Feb;62:367-71.
Chandramouli V, Ekberg K, Schumann WC, Kalhan SC, Wahren J, Landau BR. Quantifying gluconeogenesis during fasting. Am J Physiol. 1997 Dec;273(6):E1209-15.
Gerich JE, Meyer C, Woerle HJ, Stumvoll M. Renal gluconeogenesis: its importance in human glucose homeostasis. Diabetes Care. 2001 Feb;24(2):382-91.
Felig P. The glucose-alanine cycle. Metabolism. 1973 Feb;22(2):179-207.
Draoui N, Feron O. Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments. Dis Model Mech. 2011 Nov;4(6):727-32.
Ferrannini E, Barrett EJ, Bevilacqua S, DeFronzo RA. Effect of fatty acids on glucose production and utilization in man. J Clin Invest. 1983 Nov;72(5):1737-47.
Yip J, Geng X, Shen J, Ding Y. Cerebral Gluconeogenesis and Diseases. Front Pharmacol. 2016;7:521
Jiang G, Zhang BB. Glucagon and regulation of glucose metabolism. Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E671-8.
Adina-Zada A, Zeczycki TN, Attwood PV. Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA. Arch Biochem Biophys. 2012 Mar 15;519(2):118-30.
